Lifestyle choices condition colon and rectal cancer risk more than genetics

“For all my patients.”
— Dr. Dale

From Lifestyle choices condition colon and rectal cancer risk more than genetics 

Researchers of the Colorectal Cancer research group of Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Víctor Moreno, and linked to the Catalan Institute of Oncology (ICO), the University of Barcelona (UB) and the Epidemiology and Public Health CIBER (CIBEResp), have issued the first predictive risk model of colon and rectal cancer based on Spanish data that combines genetic and lifestyle information. Their work, published by Scientific Reports, highlights the importance of improving lifestyle to reduce the risk of colon cancer and suggests to use a combination of lifestyle and genetic information to subdivide the population into different groups according to their colon cancer risk, which would fine tune the current screening method.

"A risk model is a mathematical tool that allows us to predict who is most likely to suffer from a particular disease, in this case colon cancer," explains Dr. Moreno, head of ICO's Cancer Prevention and Control Program. In order to develop this model, the researchers used data from the 10,106 participants included in the "MCC-Spain" Spanish multicentre study, carried out collectively by researchers belonging to CIBEResp. All of them were interviewed to analyze known risk factors (diet, physical exercise, body mass index, alcohol and family history of cancer, among others) and in a subgroup of 1,336 cases of colorectal cancer and 2,744 controls a blood test was performed to detect the genetic predisposition to develop colon and rectal cancer.

With all this information, the research team concluded that lifestyle influences cancer risk more than genetics. They calculated that if a risky lifestyle choice is changed (for example, if a healthy weight is obtained), this can compensate for having 4 genetic risk predisposition points (risk alleles). "This is important considering that lifestyle, unlike genetic traits, is somewhat modifiable, while genetic susceptibility is inherited from our parents", says Dr. Gemma Ibáñez, a digestologist and first author of the study; "In fact, the items we have identified as risk markers correlate with the recommendations set by the European Cancer Code to reduce the risk of cancer."

"Today, screening for colon cancer in patients with no family history is based solely on age. If we include information about lifestyle and genetics, we could classify the population into groups of greater or lesser risk, which would allow us to offer a more personalized follow-up", adds Dr. Moreno, who is also a professor at the UB Faculty of Medicine and Health Sciences.

At the moment, the research team that participated in the study is conducting a new study called COLSCREEN: "Personalization of the risk of colorectal cancer" to, among other things, find out about the social perception about genetic screening. "There are no studies that say what patients think about genetic tests, or whether they want to be informed of their chances of having certain diseases, and we think it is very relevant," says Dr. Ibanez. At the same time, with this new study the researchers want to evaluate the utility of the risk score system for colon cancer by applying it prospectively in the population of Baix Llobregat.

Brain Health Guide To Red Dye #40

“An interesting read about why we should avoid foods with red dye.”
— Dr. Dale

From Brain Health Guide To Red Dye #40 

See if you can figure out what the following list of foods has in common:

  • Kraft barbecue sauce

  • Lasagna Hamburger Helper

  • Del Monte fruit salad

  • Nacho Cheese Doritos

  • Welch’s Frozen Fruit Bars

  • Duncan Hines Homestyle Vanilla Frosting

  • Schweppes diet ginger ale

  • Lipton Instant Ice Tea – Natural Lemon Flavor

  • Maraschino Cherries

Besides being an unhealthy part of the Standard American Diet, if you guessed that they all contain Red Dye #40, you’d be correct.

Horrifyingly, the food industry dumps 15 million pounds of artificial dyes into our food every year – over 40 percent of which is Red Dye #40, a petroleum-based substance. Also known as Allura Red AC, Red Dye #40 is the number one food dye used in the United States, found in most any unnaturally red foods. But you will find it in brown, blue, orange, and even white things, too. For example, without Red Dye #40, chocolate instant pudding would actually look green (because there’s VERY little real chocolate in it).

Even though there are safe and natural alternatives available, artificial food dyes are a cheap way for manufacturers to make food even brighter and more appealing when you see it on a shelf in the grocery store. Surprisingly you can find Red Dye #40 in a wide range of foods; candy, condiments, snack foods, baked goods, soda, juice, salad dressings, toothpaste, mouthwash, and even medicine, can all be artificially dyed.

Although Red Dye #40 has been approved by the FDA for use in food products and must be listed as an ingredient on labels, it has been banned at one time or another throughout Australia and most of Europe due to health concerns.

Multiple studies published in journals such as Pediatrics, The Lancet, and Journal of Pediatrics demonstrate that some children with ADHD are adversely affected by artificial food dyes. Other recent research indicates that artificial coloring and flavors, as well as the preservative sodium benzoate, can make some non-ADD kids hyperactive. Additionally, both adults and children have reported upset stomach, migraines, jitteriness, nervousness, and inability to concentrate after a high intake of Red Dye #40. The Center for Science in the Public Interest (CSPI) recently released a report that says artificial food dyes pose a “rainbow of risks” including everything from allergies to cancer.

Our brain imaging also demonstrates that Red Dye #40 can dramatically affect brain function. Consider the case of Robert, a 15-year-old that was recently imaged at Amen Clinics. His parents noticed that whenever Robert ate or drank something bright red, his behavior became aggressive and hostile. He would easily cry and storm off in a huff or throw things. They brought him to Amen Clinics to confirm their suspicions that he was reacting to these food additive.

As can be seen on this teen’s SPECT scan, his brain showed remarkable overall increased activity with exposure to Red Dye #40. In the images, blue equals average activity; red equals the top 15% of brain activity; white equals the top 8%.

Once they removed Red Dye #40 from his diet, his behavior improved dramatically. Robert’s mother strongly believes that their experience is not a unique one and that Red Dye #40 should be completely banned from our food supply.

Knowing that you are what you eat, no discussion about changing your diet for health can miss the importance of eliminating this substance!

At Amen Clinics, we want to help you learn more about your brain and how you can make it better, not only for yourself, but for the generations that follow. Call us today at 888-922-9710 or visit our website to schedule an appointment.

10 Habits Of Mentally Strong People

“To be strong a person has to learn how to increase their mental strength.”
— Dr. Dale

From 10 Habits Of Mentally Strong People  

Despite West Point Military Academy’s rigorous selection process, one in five students drop out by graduation day. A sizeable number leave the summer before freshman year, when cadets go through a rigorous program called “Beast.” Beast consists of extreme physical, mental, and social challenges that are designed to test candidates’ perseverance.

University of Pennsylvania psychologist Angela Duckworth conducted a study in which she sought to determine which cadets would make it through the Beast program. The rigorous interviews and testing that cadets went through to get into West Point in the first place told Angela that IQ and talent weren’t the deciding factors.

So, Angela developed her own test to determine which cadets had the mental strength to conquer the Beast. She called it the “Grit Scale,” and it was a highly accurate predictor of cadet success. The Grit Scale measures mental strength, which is that unique combination of passion, tenacity, and stamina that enables you to stick with your goals until they become a reality.

To increase your mental strength, you simply need to change your outlook. When hard times hit, people with mental strength suffer just as much as everyone else. The difference is that they understand that life’s challenging moments offer valuable lessons. In the end, it’s these tough lessons that build the strength you need to succeed.

Developing mental strength is all about habitually doing the things that no one else is willing to do. If you aren’t doing the following things on a regular basis, you should be, for these are the habits that mentally strong people rely on.

1. You have to fight when you already feel defeated. A reporter once asked Muhammad Ali how many sit-ups he does every day. He responded, “I don’t count my sit-ups, I only start counting when it starts hurting, when I feel pain, cause that’s when it really matters.” The same applies to success in the workplace. You always have two choices when things begin to get tough: you can either overcome an obstacle and grow in the process or let it beat you. Humans are creatures of habit. If you quit when things get tough, it gets that much easier to quit the next time. On the other hand, if you force yourself to push through a challenge, the strength begins to grow in you.

2. You have to delay gratification. There was a famous Stanford experiment in which an administrator left a child in a room with a marshmallow for 15 minutes. Before leaving, the experimenter told the child that she was welcome to eat it, but if she waited until he returned without eating it, she would get a second marshmallow. The children that were able to wait until the experimenter returned experienced better outcomes in life, including higher SAT scores, greater career success, and even lower body mass indexes. The point is that delay of gratification and patience are essential to success. People with mental strength know that results only materialize when you put in the time and forego instant gratification.

3. You have to make mistakes, look like an idiot, and try again—without even flinching.In a recent study at the College of William and Mary, researchers interviewed over 800 entrepreneurs and found that the most successful among them tend to have two critical things in common: they’re terrible at imagining failure and they tend not to care what other people think of them. In other words, the most successful entrepreneurs put no time or energy into stressing about their failures as they see failure as a small and necessary step in the process of reaching their goals.

4. You have to keep your emotions in check. Negative emotions challenge your mental strength every step of the way. While it’s impossible not to feel your emotions, it’s completely under your power to manage them effectively and to keep yourself in control of them. When you let your emotions overtake your ability to think clearly, it’s easy to lose your resolve. A bad mood can make you lash out or stray from your chosen direction just as easily as a good mood can make you overconfident and impulsive.

5. You have to make the calls you’re afraid to make. Sometimes we have to do things we don’t want to do because we know they’re for the best in the long-run: fire someone, cold-call a stranger, pull an all-nighter to get the company server back up, or scrap a project and start over. It’s easy to let the looming challenge paralyze you, but the most successful people know that in these moments, the best thing they can do is to get started right away. Every moment spent dreading the task subtracts time and energy from actually getting it done. People that learn to habitually make the tough calls stand out like flamingos in a flock of seagulls.

6. You have to trust your gut. There’s a fine line between trusting your gut and being impulsive. Trusting your gut is a matter of looking at decisions from every possible angle, and when the facts don’t present a clear alternative, you believe in your ability to make the right decision; you go with what looks and feels right.

7. You have to lead when no one else follows. It’s easy to set a direction and to believe in yourself when you have support, but the true test of strength is how well you maintain your resolve when nobody else believes in what you’re doing. People with mental strength believe in themselves no matter what, and they stay the course until they win people over to their ways of thinking.

8. You have to focus on the details even when it makes your mind numb. Nothing tests your mental strength like mind-numbing details, especially when you’re tired. The more people with mental strength are challenged, the more they dig in and welcome that challenge, and numbers and details are no exception to this.

9. You have to be kind to people who are rude to you. When people treat you poorly, it’s tempting to stoop to their level and return the favor. People with mental strength don’t allow others to walk all over them, but that doesn’t mean they’re rude to them, either. Instead, they treat rude and cruel people with the same kindness they extend to everyone else, because they don’t allow another person’s negativity to bring them down.

10. You have to be accountable for your actions, no matter what. People are far more likely to remember how you dealt with a problem than they are to recall how you created it in the first place. By holding yourself accountable, even when making excuses is an option, you show that you care about results more than your image or ego.

Bringing It All Together

Mental strength is as rare as it is important. The good news is that any of us can get stronger with a little extra focus and effort.