A colonoscopy before age 50? Here's what young people need to know about colon cancer screening

Although it is recommended to get a colonoscopy at age 50, we are never too young to start being preventative.
— Dr. Dale

A colonoscopy before age 50? Here's what young people need to know about colon cancer screening

http://pilotonline.com/news/local/health/a-colonoscopy-before-age-here-s-what-young-people-need/article_35f9498b-2d5f-5cfc-bc9a-0b9bbf4f06ef.html

Each time I visit my gastroenterologist, I can’t help but notice that I’m usually the youngest person in the waiting room by several decades.

At age 33, I’ve had two colonoscopies, even though screening guidelines recommend most people have them starting at age 50.

What’s the rush to undergo an invasive, unpleasant procedure?

Nearly six years ago, my father, then 53, was diagnosed with colon cancer. Coupled with some risk factors of my own, my doctor decided it would be best for me to undergo a colonoscopy soon after Dad’s diagnosis in 2011. I was 28.

Let’s face it: Colonoscopies are – forgive the choice of words – crappy. You go on a diet of clear liquids (Gatorade, juice, water, chicken broth) for a day. You drink a foul-tasting laxative – often, two doses. Then you spend hours in the bathroom, often in the middle of the night.

Bleary-eyed and queasy, you go to your doctor’s office, are given anesthesia or light sedation, and a doctor inserts a thin tube with a camera into your rectum. It takes about 30 minutes to examine your colon for cancer or polyps, which might develop into cancer.

It’s an unpleasant experience, but one that more people should be doing – especially in Hampton Roads.

Our region is a hot spot for colon cancer deaths, according to a study reported on by my colleague Elizabeth Simpson last year. From 2009 to 2011, southeastern Virginia and northeastern North Carolina had a colon cancer death rate 9 percent higher than the rest of the country.

Various medical organizations, as well as the U.S. government, issue colorectal cancer screening guidelines. Most, including those from the American College of Gastroenterology, call for a colonoscopy every 10 years, starting at age 50.

I called David Johnson, chief of gastroenterology at Eastern Virginia Medical School and co-author of the ACG’s screening guidelines, for some insight.

Colorectal cancers tend to be slow-growing, said Johnson, a past ACG president. Age 50 is one “where we’d recognize that we’d pick up more precancerous lesions.”

The ACG’s most recent guidelines were published in 2009. Among the biggest changes, Johnson said, was recommending that African Americans begin screening at age 45. The guidelines cite research that shows black people have an increased incidence of colorectal cancer, often at a younger age.

So – what about colon cancer in people younger than 50 or 45? I found a 2014 study from the MD Anderson Cancer Center in Texas, which examined diagnoses over a 35-year period. Researchers projected out to 2030 and found that more than one in 10 colon cancers and nearly one in four rectal cancers will be diagnosed in people younger than 50.

Johnson, who also works at Digestive & Liver Disease Specialists in Norfolk, shared a more recent study that had a similarly troubling outlook: Younger patients are more likely to be diagnosed with more advanced colorectal cancer.

What could be behind these concerning predictions? Johnson, and my doctor, Alex Williams, both said obesity and diet could contribute. Smoking, too, Johnson added.

The studies’ results beg the question: Might younger adults be included in future colorectal screening guidelines?

Williams cautioned that more studies have to be done. Johnson said he expects the review panels “to give it thoughtful and careful attention.”

So, what should young people do to protect their colon health?

Monitoring relatives’ health is important – specifically, that of parents and siblings. In the past, Williams said, people were often reluctant to share these details.

“If people don’t talk about it, if your parents don’t talk about it, there is no way you’re going to know,” said Williams, who works at Gastroenterology Associates in Norfolk. “You’ve got to ask them to be more open.”

Grandparents’ colon cancer isn’t especially a factor for grandchildren, Williams said, unless they are diagnosed at a young age – around 40.

One of the most important things is: No matter your age, don’t ignore problem signs, like blood in the stool or a change in your bowel output.

“Those should never be taken as, ‘Well I’m too young to be getting these things,’ “ Johnson said. “Patients should always report things and never be their own diagnostician.”

The tricky thing about colon cancer is it can be a silent killer. By the time symptoms show up, Williams said, it’s often rather advanced.

That was certainly the case for my dad. He had been experiencing sporadic hand cramps, and when he went to the doctor, his bloodwork showed severe anemia.

Within weeks, he had a colonoscopy to look for internal bleeding – his first since around age 40. And that’s where his Stage 2 cancer was found.

He had part of his colon removed. Five years later, he’s a cancer survivor.

To say my dad was fortunate would be understating it. He had symptoms. He had surgery, and no chemotherapy or radiation was needed.

As Johnson put it, the goal of colorectal screening isn’t to detect cancer, it’s to prevent cancer. With any luck, I, and others who vigilantly monitor their digestive health, can avoid a cancer diagnosis, too.

Less Cervical Cancer Screening in HPV-Vaccinated Population?

An interesting read for my female patients.
— Dr. Dale

Less Cervical Cancer Screening in HPV-Vaccinated Population

http://www.medscape.com/viewarticle/870834#vp_2

However, he also warns that the option to screen less intensively at a later age with HPV testing instead of cytology may not be an option for all HPV-vaccinated women. There is a greater chance that women who received "catch-up vaccination" after the age of 12 became sexually active prior to vaccination, thereby increasing their risk for infection by vaccine HPV types, he explains.

"Current prophylactic HPV vaccines do not treat preexisting infections and related conditions, and therefore the population cancer risk reduction from HPV vaccines is lower in older populations," he writes.

A risk-based approach to clinical decision-making should be extended to cohorts vaccinated after the age of 12, he advises.

"Lower and upper risk thresholds, defining a risk band, should be established to decide at what age screening starts, at what frequency, and when it stops, as well as who would benefit from colposcopy with biopsy and even treatment without a confirmatory biopsy, should the risk be sufficiently high."

"Importantly," he adds, "these risk-based recommendations for clinical actions must to be conveyed to the busy clinician in a simple, clear, and direct manner."

Microsimulation Model of Different Screening Strategies

In the study, researchers used an individual-based microsimulation model of HPV and cervical cancer to project the health benefits, costs, and harms associated with different screening strategies. They looked at women vaccinated with the bivalent vaccine (HPV-2) or the quadrivalent vaccine (HPV-4) or the nonavalent vaccine (HPV-9).

Strategies varied according to whether primary screening involved cytology or HPV testing or a combination of both. Strategies also varied with respect to the age at which screening started, the interval between routine screens, and whether screening tests changed.

Cost-effectiveness was analyzed using thresholds of $50,000 to $200,000 per quality-adjusted life years (QALY) gained.

The study showed that for women who received the bivalent or quadrivalent HPV vaccines, the most cost-effective strategy was either cytology or HPV testing alone, beginning at age 25 or 30 years and repeated every 5 years

For women who received the first-generation vaccines, the cost-effectivesness of such screening ranged from $34,680 to $138,560 per QALY gained. First-generation vaccines protect against HPV16 and HPV18, which together are responsible for about 70% of cervical cancer.

It was not cost-effective to start screening earlier or to perform it more frequently, the investigators write. In women vaccinated with the later nonavalent vaccine HPV-9 — which also protects against five additional carcinogenic HPV genotypes — HPV testing alone every 10 years was efficient, the study showed. Such testing could begin at age 35 years, at a cost of $40,210 per QALY, or at age 30 years, at a cost of $127,010 per QALY.

The mean reduction in lifetime risk for cervical cancer in women vaccinated with HPV-9 was 85.3% in comparison with no intervention, the study showed. With the addition of screening, reductions in lifetime cancer risk ranged from 91% to 99%.

"Given the lower baseline disease risk in women vaccinated with HPV-9, the optimal screening strategies involved later start ages and lower frequencies than for women vaccinated with HPV-2 or HPV-4," the researchers say. "Furthermore, only strategies that involved primary HPV testing were efficient."

The screening strategies in HPV-vaccinated women led to nearly equivalent health benefits in terms of QALYs and reductions in lifetime cancer risk as the screening intensity increased, especially for women vaccinated with the nonavalent vaccine, the researchers note. "The 10-year screening interval in women vaccinated with HPV-9 remained most efficient throughout," they say.

A 10-year screening interval for cervical cancer was also proposed recently by Dutch researchers, as reported by Medscape Medical News.

Frozen Strawberries recalled as part of hepatitis A outbreak investigation

A public announcement that is important to keep in mind when grocery shopping.
— Dr. Dale

Frozen strawberries recalled as part of hepatitis A outbreak investigation

http://wric.com/2016/11/01/frozen-strawberries-recalled-as-part-of-hepatitis-a-outbreak-investigation/

RICHMOND, Va. (WRIC) — The International Company for Agricultural Production & Processing (ICAPP) is voluntarily recalling certain lots of its frozen strawberries imported into the U.S. since the start of 2016 “out of an abundance of caution.”

The recall is in response to a U.S. Food and Drug Administration (FDA) investigation of an outbreak of Hepatitis A. At the end of August, a statewide Hepatitis A scare was linked to frozen strawberries at Tropical Smoothie Cafe restaurants and other locations.

The Virginia Department of Health has reported more than 100 cases of Hepatitis A in Virginia due to contaminated strawberries imported from Egypt. Three lawsuits have been filed on behalf of the victims, including one person from Richmond and another from Chester.

Those represented in the lawsuit bought smoothies from the chain. Soon after, they all fell ill with Hepatitis A and experienced typical symptoms of the disease, which include fever, nausea, vomiting, headaches, abdominal pain, and fatigue.

Persons who may have consumed affected product should consult with their health care professional or local health department to determine if a vaccination is appropriate and consumers with symptoms of Hepatitis A should contact their health care professionals or the local health department immediately.

For questions or more information, you can contact ICAPP by email at customerservice@icapp.com.eg or by phone, between 9:00 am and 5:00 pm Cairo local time, at +201-541-1624.